Metastatic prostate cancer: Treatment and prognosis

Prostate cancer occurs when the cells in the prostate start to grow uncontrollably.

At times, prostate cancer grows rapidly and spreads to other organs. This is called stage IV prostate cancer also is supposedly metastatic.

What’s the prostate?

Prostate highlighted in 3D model of male anatomy.
The prostate is a small organ which plays a part in protecting semen and making semen.

The prostate gland is a small, walnut-shaped manhood which sits between the bladder and rectum in males.

During puberty, sperm cells move from the testicles through the seminal vesicles into the thyroid gland. The prostate secretes particular fluids which assist the sperm cells endure.

This mixture of sperm and fluid cells is referred to as semen, and it leaves the body via the urethra.

What’s metastatic prostate cancer?

Oftentimes, prostate cancer grows very slowly; so gradually in reality, that lots of guys do not even understand they’ve the disorder. In different guys, but the disorder metastasizes — spreads to organs out of the place it originated.

There are two Kinds of prostate cancer cancer:

  1. Neighborhood metastasis: prostate cancer using local metastasis usually means the cancer has spread into other organs inside the pelvis. This typically means that the local lymph nodes, but may incorporate any structure or organ in the anus.
  2. Distant metastasis: Distant metastasis usually means the prostate cancer has spread beyond the pelvis. The bones, lungs, spine, liver, brain, and lungs are most typical forms of cancer metastasis.


Man experiencing painful urination because of a prostate problem.
Possible signs of prostate cancer include trouble urinating, pain during urination, and an awareness of having to urinate urgently.

Signs of prostate cancer may include:

  • Urinary urgency
  • trouble stopping or starting breastfeeding
  • weak or interrupted urine flow
  • painful or burning urination
  • erectile dysfunction
  • debilitating ejaculation
  • blood into the urine or sperm

Anyone experiencing these symptoms should talk to their physician whenever possible. While many different illnesses may cause severe symptoms, it’s crucial to rule out prostate cancer.

When a individual was diagnosed with prostate cancer, then the signals of metastasis will be different based upon precisely in which the cancer develops and how fast it’s growing.

As an instance, a individual who has prostate cancer along with neighborhood metastasis to lymph nodes nodes might not encounter any change in symptoms.

But a individual who has metastasis to the bones can experience bone pain.

Other Signs of metastasis could include:

  • Tiredness
  • feeling unwell
  • diminished appetite
  • weight-loss
  • swelling in your feet or legs


Advanced prostate cancer can cause many other health issues based on where the cancer has spread into and also just how fast it’s spreading.

  • Urinary problems: Cancerous growths may press to the bladder, urethra, or other organs. Prostate cancer may also spread to all those organs and lead to urinary retention, and blood in the feces, incontinence, also problems draining the bladder.
  • Bowel issues: Advanced prostate cancer may lead to bowel problems, for example constipation, nausea, urgency, obstruction, and incontinence. This can be as a result of use of pain medicines, or even the spread of prostate cancer into the intestine or rectum. Dietary alterations, dehydration, and childbirth may also lead to bowel issues.
  • Sexual issues: It isn’t unusual for men with advanced prostate cancer to have problems getting or keeping an erection. Some guys also have diminished libido or a chance to semen.
  • Bone fractures or pain: prostate cancer which has spread into the bones may cause considerable bone loss pain. In addition, it can weaken your bones, which makes a individual susceptible to fractures and also fractures.
  • Hypercalcemia: iodine is stored in the bones may flow out to the bloodstream if prostate cancer spreads to the bones. Elevated levels of Vitamin calcium from the bloodstream may lead to fatigue, increased appetite or will need to urinat nausea and vomiting, constipation, and loss of desire.
  • Anemia: Anemia usually means a reduction in the amount of red blood cells which are readily available to carry oxygen through your body. This may result in severe tiredness, shortness of breath, and looking pale. It’s generally brought on by cancer that has spread into the bone marrow but may also be a complication of cancer therapies.
  • Lymphedema: prostate cancer which has spread into the lymph nodes may cause blockages inside the vessels which transport lymph throughout the entire body. This causes swelling in your legs or scrotum.


There are various kinds of remedies offered for prostate cancer. A physician or oncologist may create a treatment program which takes into consideration the person’s symptoms, outlook, goals for therapy, age, and overall wellness.

Hormone treatment

Hormone treatment for prostate cancer evolves down the generation of male hormones. This might help stop the cancer in continuing to develop. Frequent medications contain abiraterone (Zytiga) along with enzalutamide (Xtandi).


Chemotherapy is a sort of medicine that destroys cancer cells prevents them from multiplying. Individuals are often provided chemotherapy when the prostate cancer has ceased responding to hormone treatment.

Chemotherapy is generally a mixture of at least two drugs which are administered orally, injected, or taken as a tablet computer.


Immunotherapy is a form of medicine that modifies the human body’s immune system to locate and destroy cancer cells.

Therapy for prostate cancer which has spread into the bones contains drugs like zoledronic acid (Zometa) and denosumab (Xgeva). Remedy for neighborhood metastatic cancer might also incorporate radiation treatment.

Negative effects of prostate cancer therapy

Prostate cancer treatment may cause some serious unwanted effects, such as:

Senior male patient speaking to young male doctor.
Prostate cancer therapies can cause several side effects which needs to be summarized with a medical specialist ahead.
  • Infertility
  • urinary incontinence
  • urinary retention
  • nausea
  • ed
  • pain
  • tiredness
  • baldness
  • reduction of desire
  • nausea and vomiting

Fortunately, there are lots of drugs available to care for the side effects of cancer therapy.

Someone should not believe that the necessity to “energy through” or suffer with embarrassing symptoms. It’s very important to anybody undergoing therapy to speak with their health care team about any negative effects they’re experiencing.


The prognosis for prostate cancer is dependent upon where the cancer has spread and how sharply it’s growing.

According to the American Cancer Society, survival rates have been as follows:

  • Nearby prostate cancer without disperse includes a 5-year success rate in almost 100 percent.
  • Prostate cancer using local spread also includes a 5-year success rate in almost 100 percent.
  • Prostate cancer with distant metastasis includes a 5-year survival rate of about 29 percent.

These are overall data; it’s essential for a individual who has prostate cancer to talk to their physician about their particular case.


When prostate cancer is diagnosed before it has spread, or whether it’s spread to neighboring structures, then the survival rate is great.

This makes regular screening and early identification required in the battle against prostate cancer.

Men over age 50 should talk to a healthcare practitioner in regards to the various screening options and that is most suitable to them.

Courtesy: Medical News Now